Active transport of gamma-aminobutyric acid and glycine into synaptic vesicles.
نویسندگان
چکیده
منابع مشابه
Demonstration of functional coupling between gamma -aminobutyric acid (GABA) synthesis and vesicular GABA transport into synaptic vesicles.
l-Glutamic acid decarboxylase (GAD) exists as both membrane-associated and soluble forms in the mammalian brain. Here, we propose that there is a functional and structural coupling between the synthesis of gamma-aminobutyric acid (GABA) by membrane-associated GAD and its packaging into synaptic vesicles (SVs) by vesicular GABA transporter (VGAT). This notion is supported by the following observ...
متن کاملActive transport of y - aminobutyric acid and glycine into synaptic vesicles ( neurotransmitter / Mg - activating ATPase / proton gradient / brain / spinal cord ) PHILLIP
Although y-aminobutyric acid (GABA) and glycine are recognized as major amino acid inhibitory neurotransmitters in the central nervous system, their storage is poorly understood. In this study we have characterized vesicular GABA and glycine uptakes in the cerebrum and spinal cord, respectively. We present evidence that GABA and glycine are each taken up into isolated synaptic vesicles in an AT...
متن کاملGamma aminobutyric acid and glycine receptors in the nucleus
Gamma aminobutyric acid and glycine receptors in the nucleus ambiguus mediate 1 tachycardia elicited by chemical stimulation of the hypothalamic arcuate nucleus 2 3 Vineet C. Chitravanshi, Kazumi Kawabe and Hreday N. Sapru 4 5 Department of Neurological Surgery, Rutgers New Jersey Medical School, 185 South Orange 6 Avenue, Newark, NJ 07103, USA 7 8 9 10 Short title: Arcuate nucleus: heart rate ...
متن کاملGABA and glycine in synaptic vesicles: storage and transport characteristics.
gamma-Aminobutyric acid (GABA) and glycine are major inhibitory neurotransmitters that are released from nerve terminals by exocytosis via synaptic vesicles. Here we report that synaptic vesicles immunoisolated from rat cerebral cortex contain high amounts of GABA in addition to glutamate. Synaptic vesicles from the rat medulla oblongata also contain glycine and exhibit a higher GABA and a lowe...
متن کاملP146: Gamma Aminobutyric Acid (GABA) and its Alterations in Stress
Gamma aminobutyrate (GABA) is a non-protein amino acid that is thought to play an important role in the modulation of the central response to stress. Mechanisms by which GABA may facilitate these responses to stress are metabolic and/or mechanical disruptions. Environmental stresses increase GABA accumulation through cytosolic acidification, induce an acidic pH-dependent activation of glutamate...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1989
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.86.10.3877